AIDS

Men Can Help Stop The Spread of HIV to Infants and Children

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Together with GHC CEO, Barbara Bush, find out how Men can help STOP the spread of HIV to Infants and Children: http://www.huffingtonpost.com/barbara-bush/how-can-men-help-stop-the_b_5862200.html

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Will Uganda have a “Mississippi Baby”?

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Last week, was it was reported that the Mississippi baby previously thought to be cured of HIV was in fact carrying detectable amounts of the virus.

The child, born in 2010 to an HIV-positive mother who received no prevention of mother-to-child transmission of HIV (PMTCT) services during her pregnancy, tested positive for HIV shortly after birth. She was given a high dose of antiretroviral medications at 30 hours of age and remained on antiretroviral therapy (ART) for 18 months before she was lost to follow-up care.

Five months after being lost to care, the child was again examined by medical staff and found to have undetectable levels of HIV, and remained so for more than two years. This was the basis of her Care and Treatment advisors declaring her cured.

This month, at almost 4 years of age, detectable levels of HIV were found in the child’s blood, along with a decreased level of CD4 T-cells and the presence of HIV antibodies—signals that the virus is actively replicating in the body. According to NIH, the baby had (16,750 copies/mL). Repeat viral load blood testing performed 72 hours later confirmed this finding (10,564 copies/mL of virus).

Additionally, the child had decreased levels of CD4+ T-cells, a key component of a normal immune system, and the presence of HIV antibodies—signals of an actively replicating pool of virus in the body. Based on these results, the child was again started on antiretroviral therapy. To date, the child is tolerating the medication with no side effects and treatment is decreasing virus levels. Genetic sequencing of the virus indicated that the child’s HIV infection was the same strain acquired from the mother.

There are a number of things that caught my attention when i read up the details on this story:

  1. That a mother went to deliver in the hospital, even though she had not received PMTCT services during her pregnancy – this is something for which we are yet to achieve 50% as a nation. Are we able to reverse this? Because whenever a mother does not deliver from the facility, its not only a missed opportunity to test for HIV, it means we cannot catch other birth related complications, and as such we continue to stare into grim figures of Maternal and Neonatal deaths.
  2. There was a lab and test kits to test for HIV, and CD4 count of the baby at the various stages of development. Is this something that we can ensure? What is the proximity of an HIV testing centre to the 2.2 million ugandan babies born annually? As you can imagine, the presence of a lab is inconsequential if the reagents and test-kits are not present. In many areas where the labs are not present, regional hubs function to carry out the tests. A sample transportation network is critical for DBS samples for exposed infants, indeed for all children and mothers.
  3. One of the salient successes of this story is documentation – the presence of mind to notice something unusual at your job, and you take a keen interest in it, choosing to follow it up and ask the questions that some people may consider hard to ask. I wonder if we are able to take a keen interest in something scientifically unusual and cause it to be the centre of a full fledged research, as this case turned out to be.
  4. How about the patience to look at the numbers (facts and figures) 4 years later? In science, this institutional memory is very important, because it makes for very interesting research findings all the time. Every picture, every story, every record, as long as it is not treated with contempt, has the potential to reveal something to us if we listen to the numbers more closely. And yes, sometimes, its years later, but if we are keen, we will hear the numbers speak to us.

As the world of science grapples with the apparent set back, players and actors in the sector remain committed to advancing HIV/AIDS research. With programs that focus on HIV prevention and treatment as the best tools to end pediatric HIV international and national partners are making great strides toward eliminating mother-to-child transmission of HIV globally.

Right now, we know, that by providing a pregnant or breastfeeding  HIV positive woman ART we can almost completely eliminate the possibility that she will pass the virus onto her baby during pregnancy, child birth, or breastfeeding. However, every day 700 children become newly infected with HIV. We must quickly identify and begin treating these children to ensure they can lead healthy lives.

As a nation, our job isn’t over until no child has AIDS. Uganda must ensure that communities and health facilities have the tools they need and the resources to plan, implement, and sustain their HIV programs so that all families are reached with services. Otherwise, Uganda will never have a Mississippi Baby.

Want an HIV Free Generation? Support p/eMTCT.

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30 year old Jessica (not real names) is a single mother of a 4 year old gal, and a 2 year old boy. She grew up in the hills near Kabale, in what she calls a “proper christian home with strict parents.” The second of 5 children, Jessica lives with her mother, having lost her father as early as 1990. The 5th wife of her husband, Jessica conceived within the first year of her marriage, only getting knowledge of her HIV status in her 1st trimester. Jessica lost no time in getting into ART Care and Therapy.

In 2009, having been exposed to PMTCT services, Jessica delivered her first born daughter, HIV Negative. Excited at the possibility, Jessica knew she could hold onto her dream of having a family, and in 2011, Jessica delivered her second child, HIV Negative. Jessica is one of hundreds of thousands of women who have seen the fruits of the intervention to prevent the transmission of HIV virus from a mother to her unborn child.

When my organization, the Elizabeth Glaser Pediatric AIDS Foundation started to implement the USAID funded STAR-SW, there were only 100 accredited sites to offer PMTCT services in 13 districts in the South Western region of Uganda. Today, there are over 220 PMTCT accredited sites.

Today, the problem of health workforce is not in the numbers, rather in their technical capacity to support fully the elimination of mother to child transmission of HIV (eMTCT). And whether this capacity is well harnessed and managed so that every mother who comes to the facility will find a competently equipped health worker to attend to them. Where the numbers remain wanting, Peer educators have been used to stop gap non-technical areas, so that the few health workers present could be utilized maximally. There are many facilities that could use peer educators, in some cases, needing upto 6 in the HIV/ART Clinic.

For health workers to be present, without the logistics they need to perform their work is disheartening. eMTCT programs are premised on the presence of HIV Test kits, the presence of ARVs pre and post-delivery, both for mother and baby. Incidentally, mothers can be initiated on ART Care without the presence of complex and expensive equipment in a state of the art laboratory. But whenever a facility does not have these essentials, then the consistency of the intervention is greatly undermined. The question of logistics has a flip side, whether a health center is an accredited site to receive and offer PMTCT services. While I understand the dynamics of this, I also realize that the size of pandemic that HIV is, that we should indeed consider to have this intervention at the nearest health facility to a mother who we would not like to deliver at home, unattended to, and who will inadvertently pass the HIV virus to her unborn child.

South Western Uganda communities also have taught me an important lesson – that when men are not involved in the seeking of eMTCT services, then we do not have a sustainable intervention. Men are key, and in some cases kings. But men have escorted their pregnant partners to the facility only to sit under a tree for 2 or 3 hours, unattended to and completely detached from the details of an ANC visit. Indeed, some health workers do not know what to do for men, other than HCT for which couple testing is rewarded with a certificate. There must be, on offer, a package suited towards men that will give them a sense of belonging and connection to the health care of their HIV positive partner, beyond HCT. Here, is opportunity for innovation.

Often, when HIV positive mothers leave the facility, they go into a stigmatized community and some of them are lost to care and treatment at the facility. We need to continue to take a detailed look at the linkages between the facilities and the communities. The use of peer educators could be a terrific solution for this. For example, staff at Ntungamo district’s Itojo Hospital have devised a plan, to assign each peer between 5-6 mothers who live in the same neighbourhood as they do. They will check on them at home, and ensure that they remain plugged into Care and Treatment; and in some cases serve as treatment buddies.

But we can do so much more with community leaders – parish chiefs, religious leaders, sub-county chiefs, model men, opinion leaders – they can all help to shape a dialogue, at community level that will stem so many negative attitudes and cause us to

To date, we have seen over 2 million mothers access and receive PMTCT services, but we cannot remain complacent, the next mother in line is equally as important as the one we have served. And we are going to need all hands on deck, Men, trained health workers, adequate supplies, and a conducive environment. Together, we can bring about an HIV Free generation, together, we can eliminate mother to child transmission of HIV.